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Mary Theriault Office 401-762-2000 ext. 21 mtheriault@onsettx.com

Onset Therapeutics Announces That New Topical Anesthetic, Anestafoam^TM, is Now Available

Cumberland, RI (March 25, 2008) – Onset Therapeutics, a specialty pharmaceutical company that focuses on the development and commercialization of innovative treatments for skin and skin related disorders, announced that patients can now purchase Anestafoam^TM on-line through www.dermadoctor.com. Anestafoam^TM, a novel topical foam formulation containing lidocaine 4%, is the first and only foam formulation of lidocaine on the market.

Anestafoam^TM is indicated for the temporary relief of pain associated with minor cuts and scrapes, abrasions, skin irritation, sunburn, burns and insect bites, and it incorporates the Company’s proprietary Delevo^TM Foam Technology, which utilizes a semi-solid emollient micro-emulsion system to deliver the active ingredient rapidly and efficiently. Failure to efficiently release the active(s) from topical formulations can delay the onset of activity and thus reduce the effectiveness of the product. In addition, the Delevo^TM foam is alcohol-free, easy to spread over large areas of the body, and leaves no messy residue after absorption into the skin. All of these attributes can lead to higher patient acceptability ratings and patient compliance.

Aside from on-line availability through www.dermadoctor.com, Anestafoam^TM is also available for patient purchase through retail drug stores and dispensing dermatologists. Dermatologists can purchase Anestafoam^TM directly from the manufacturer or through a distributor.

“Product availability and ease of access for patients are extremely important to dermatologists”, commented Mary Theriault, Director of Marketing of Onset Therapeutics. “In addition to the option of dispensing out of the dermatology practice and the traditional stocking at local retail pharmacies, on-line distribution channels offer patients the flexibility of purchasing Anestafoam^TM from the comfort of their own home.” Please call (866) 213-8975 if you would like additional information about Anestafoam^TM.

About Onset Therapeutics

Onset Therapeutics, a wholly owned subsidiary of Collegium Pharmaceutical (www.collegiumpharma.com), is a specialty pharmaceutical company focusing on the development, manufacturing and commercialization of novel, patent protected topical products for the treatment of skin and skin related disorders. The Company’s currently marketed products include: Kerafoam®, Clarifoam^TM EF, Optase® and Paptase®. In addition, Onset has an extensive pipeline of products in development utilizing its proprietary DELEVO^TM foam technology. For more information, please visit the company’s website at www.onsettx.com

About DERMAdoctor.com

DERMAdoctor.com is a leading website dedicated to skin health, with articles, newsletters, tips, and FAQs concerning all skin conditions. Founded in 1998 by leading dermatologist Audrey Kunin, M.D., DERMAdoctor.com offers a wide range of skin care products personally selected by Dr. Kunin for their efficacy.